Protein Details: Calcium-activated chloride channel regulator 1

Protein ID

ICDB_Pro_1470

Protein Name

Calcium-activated chloride channel regulator 1

Gene Name

Clca1; Clca3; Gob5

Organism

Mus musculus (Mouse)

Length

913 amino acids

AlphaFoldDB

AF-Q9D7Z6-F1-model_v4.pdb

Function

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia; mucus hypersecretion; cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.

Sequence

MESLKSPVFLLILHLLEGVLSESLIQLNNNGYEGIVIAIDHDVPEDEALIQHIKDMVTQASPYLFEATGKRFYFKNVAILIPESWKAKPEYTRPKLETFKNADVLVSTTSPLGNDEPYTEHIGACGEKGIRIHLTPDFLAGKKLTQYGPQDRTFVHEWAHFRWGVFNEYNNDEKFYLSKGKPQAVRCSAAITGKNQVRRCQGGSCITNGKCVIDRVTGLYKDNCVFVPDPHQNEKASIMFNQNINSVVEFCTEKNHNQEAPNDQNQRCNLRSTWEVIQESEDFKQTTPMTAQPPAPTFSLLQIGQRIVCLVLDKSGSMLNDDRLNRMNQASRLFLLQTVEQGSWVGMVTFDSAAYVQSELKQLNSGADRDLLIKHLPTVSAGGTSICSGLRTAFTVIKKKYPTDGSEIVLLTDGEDNTISSCFDLVKQSGAIIHTVALGPAAAKELEQLSKMTGGLQTYSSDQVQNNGLVDAFAALSSGNAAIAQHSIQLESRGVNLQNNQWMNGSVIVDSSVGKDTLFLITWTTHPPTIFIWDPSGVEQNGFILDTTTKVAYLQVPGTAKVGFWKYSIQASSQTLTLTVTSRAASATLPPITVTPVVNKNTGKFPSPVTVYASIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKNDGVYSRFFTAFDANGRYSVKIWALGGVTSDRQRAAPPKNRAMYIDGWIEDGEVRMNPPRPETSYVQDKQLCFSRTSSGGSFVATNVPAAAPIPDLFPPCQITDLKASIQGQNLVNLTWTAPGDDYDHGRASNYIIRMSTSIVDLRDHFNTSLQVNTTGLIPKEASSEEIFEFELGGNTFGNGTDIFIAIQAVDKSNLKSEISNIARVSVFIPAQEPPIPEDSTPPCPDISINSTIPGIHVLKIMWKWLGEMQVTLGLH

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 156; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 160; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 167; /ligand="Zn(2+)"; /ligand_note="catalytic";

Disease

Location

Exclusively expressed in the digestive and respiratory tracts and in the uterus (at protein level). Expressed in small intestine; colon; stomach; and uterus and slightly expressed in trachea tissue. Exclusively expressed in the mucin granule membranes of gastrointestinal; respiratory; and uterine goblet cells and other mucin-producing cells. Exclusively expressed in the mucin granule membranes of gastrointestinal; respiratory; and uterine goblet cells and other mucin-producing cells. Exclusively expressed in the mucin granule membranes of gastrointestinal; respiratory; and uterine goblet cells and other mucin-producing cells. In the colon; expressed in the surface mucous cells. In the stomach highly expressed in the surface epithelium in the pylorus. Strongly expressed in the airway epithelium of lung tissues associated with airway hyperresponsiveness (AHR).

DOI ID

10.1006/bbrc.1999.0168; 10.1165/ajrcmb.25.4.4578; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1073/pnas.081510898; 10.1177/002215540205000609; 10.1016/s0002-9440(10)61212-6; 10.1074/jbc.m504654200; 10.1074/mcp.m500098-mcp200; 10.1165/rcmb.2005-0451oc; 10.1074/jbc.m606489200

RefSeq

NP_059502.1